I really like this hook, and agree with everyone that "paralyzed from the waist down" is much more dramatic than wheelchair user and doesn't sound derogatory at all.
My only suggestions are stylistic.
Paralyzed from the waist down, 17 year old Nadia must flee across the war torn Ukrainian countryside (e.g. no need to mention hometown). As a side note, is there a reason that the enemy forces are looking for her in particular? it seems odd that they'd try to capture her. If there is some reason, that might be good to include in the query (e.g. Nadia must flee before the enemy forces capture her and the secret military plans she is carrying, or something like that).
it'd also be nice to get some idea of the time period. Is this set in a specific historical conflict? Is it in the near future? If so, you should mention that in the query. (It's 2011 and Nadia must flee...)